Experts believe a mutation to the FMO3 gene causes it. Who else in my family should I test for trimethylaminuria? What Causes Body Odor and How Can I Treat It? Participating in research helps researchers ultimately uncover better ways to treat, prevent, diagnose, and understand human diseases. These may make it easier to wash off TMA from the skin. (2010). Many collaborate with medical experts and researchers.Services of patient organizations differ, but may include: Clinical studies are part of clinical research and at the heart of all medical advances, including rare diseases. Gene testing is currently available only through research laboratories. People with trimethylaminuria have an impaired version of the enzyme flavin-containing monooxygenase 3 (FMO3). offers rare disease gene variant annotations and links to rare disease gene literature. A doctor can help put together a treatment plan that includes dietary and lifestyle changes. Diplomate, American Board of Internal Medicine. In our experience, trimethylaminuria Even without mutations to FMO3, some people may experience trimethylaminuria from an intake of large doses of TMA or products that increase TMA production. Nat Genet 17:491-494, 1997). An article about trimethylaminuria, written by Damaris Christensen, and published by ScienceNewsOnline, Volume 155, Number 20 (May 15, 1999), Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients. A doctor may be able to diagnose trimethylaminuria by asking a person about their symptoms and carrying out a few tests. WebIn trimethylaminuria, the body is unable to turn a strong-smelling chemical called trimethylamine produced in the gut when bacteria break down certain foods into a There are several reports that the condition worsens around puberty. Problems with memory, senses, or mood may also occur. L-carnitine, a supplement that is popular with athletes, choline, an ingredient used in treatments for Huntingtons and Alzheimers diseases, lecithin, an additive that features in a range of health supplements, brassica vegetables, such as cabbage, cauliflower, broccoli, and Brussels sprouts, taking a laxative to lessen the time that food takes to pass through the digestive tract, which can help reduce the amount of trimethylamine that the gut produces, if possible, avoiding situations or activities that cause, 750 milligrams (mg) of activated charcoal twice a day, for 10 days. Last reviewed by a Cleveland Clinic medical professional on 02/04/2022. As this TMA builds up in the body, it causes the body to give off a strong odor. Usually, an enzyme breaks down trimethylamine as part of the digestion process. preti@monell.org Bushdid C, et al. You may have or believe that you have trimethylaminuria (TMAU), which is a rare disorder that causes the body to constantly emit a foul odor that cannot be stopped through maintaining good personal hygiene. A listing of information and links for finding comprehensive genetics health information online. In women, symptoms can worsen just before and during menstrual periods, after taking oral contraceptives, and around menopause. However, it may be possible to reduce the bad odor by taking different steps. A second urine specimen should then be collected post-choline load, about 12 hours after the patient has ingested choline bitartrate with a glass of orange juice or water [5000 mg of choline bitartrate for patients >12 years and weighing >54 kg (120 lbs); 2500 mg for patients aged >12 years and weighing < or = 54 kg (120 lbs)]. (MedlinePlus), Learn more about the different types of clinical studies, ResearchMatch helps connect people interested in research studies, UMLSVocabulary Standards and Mappings Downloads, Access aggregated data from Orphanet at Orphadata, National Center for Biotechnology Information's, Newborn Screening Coding and Terminology Guide, Improving newborn screening laboratory test ordering and result reporting using health information exchange, Health Literacy Online: A Guide for Simplifying the User Experience, U.S. Department of Health & Human Services, National Center for Advancing Translation Sciences, Ways to connect to others and share personal stories, Up-to-date treatment and research information, Lists of specialistsor specialty centers. Trimethylaminuria is usually inherited in an autosomal recessive fashion, which means that two non-functioning FMO3 genes are usually needed for a person to have symptoms. If sequencing the FMO3 gene does not uncover mutations, the gene can be analyzed for large deletions or duplications of 'letters' of the gene. Mutations to FMO3 are generally inherited in a recessive pattern, meaning both parents are at least carriers of one copy of the mutated FMO3 gene. However, choline is an essential nutrient that is needed by your body for many functions. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. It is inherited in an autosomal recessive pattern. We avoid using tertiary references. While trimethylaminuria does not typically have any other physical symptoms besides a fishy odor, it can cause people to socially isolate themselves and lead to depression. The sq. A 2004 article by some of the same scientists on the 2008 USDA report includes a table of choline-rich foods. Here, we look at the causes, symptoms, and treatment of trimethylaminuria. All You can find a genetic counselor in your area by using the "Find a Genetic Counselor" tool on the National Society of Genetic Counselors website. Consult doctors, other trusted medical professionals, and patient organizations. More than 100 cases have been reported in medical literature, but some clinicians believe its underdiagnosed. Connect with a Genome Medical care coordinator and make your appointment online. What are the symptoms of trimethylamineuria? However, it is possible for people with this condition to live normal, healthy lives. Enroll in databases to allow researchers from participating institutions to find you. Note: This laboratory may have a long waiting list of patients. Trimethylaminuria (TMA) with Creatinine Testing J Inher Metab Dis 26 (Suppl 2): (448-P) 224. They may offer online and in-person resources to help people live well with their disease. References. But a combination of diet, hygiene and some medications can help make trimethylaminuria symptoms less noticeable. Healthy volunteers may also participate to help others and to contribute to moving science forward. Finding Reliable Health Information Online You should use the resources on this page to help you discuss TMAU with your PCP. Is the ketogenic diet right for autoimmune conditions? Trimethylaminuria may be caused by a variety of genetic changes to the FMO3 gene. Email: LabClientServices@childrenscolorado.org. If you have not received this confirmation email the please check your spam folder or resend your question after verifying your email. An electronic catalog of human genes and genetic disorders, developed by the National Center for Biotechnology Information (NCBI). Anyone from the U.S. can register with this free program funded by NIH. Our mission is to help guide individuals to the answers for their genetic questions and decrease the time it takes to get a diagnosis. View more property details, Last medically reviewed on March 15, 2022. Philips IR, et al. DNA is composed of 'letter', A, C, T, and G. With this testing, the FMO3 gene is sequenced; meaning each 'letter' of the gene is read to look for 'misspellings'. Other people develop a form of trimethylaminuria thats called secondary, acquired or transient trimethylaminuria. Your password has been reset successfully. To find out more about our partnership, click here. Talk to a trusted doctor before choosing to participate in any clinical study. Some people have a mutation in the gene that controls this enzyme, which prevents it from breaking down certain chemicals properly. Include your email address to get a message when this question is answered. The condition is caused by a homozygous mutation in the FMO3 (flavin monooxygenase 3) gene coding for the enzyme that converts TMA (trimethylamine) to trimethylamine N-oxide. Certain supplements may help reduce the amount of trimethylamine in a persons urine. Online Mendelian Inheritance in Man (OMIM) [omim.org] TMAU may not seem like a major health problem, but people who have trimethylaminuria often struggle with psychological and social issues. Get useful, helpful and relevant health + wellness information. If you have trimethylaminuria, it means your body cant process a bad-smelling chemical called trimethylamine. People can also avoid using alkaline soaps and body lotions with a high pH level. Policy. This changed gene cant give instructions for making the FMO3 enzyme. Healthcare providers may recommend you avoid the following foods: Eliminating these foods may reduce the amount of essential nutrients choline and folate, so ask your healthcare provider about ways to ensure you have enough choline and folate. Last medically reviewed on November 14, 2022. Trimethylaminuria is a rare condition that causes a buildup of the chemical trimethylamine in the body. If living with TMAU has made you feel isolated, angry, anxious or depressed, you may benefit from some mental health support. Thanks for contacting us. They increase the amount of TMA in the body. Your experience may be different from others, and you should consult your primary care provider for more information. When two carriers of an autosomal recessive condition have children, each child has a 25% (1 in 4) chance to have the condition, a 50% (1 in 2) chance to be a carrier like each of the parents, and a 25% chance to not have the condition and not be a carrier. You may also wish to try using soaps and lotions with a pH level of 5.5 to 6.5. Find resources for patients and caregivers that address the challenges of living with a rare disease. Taking riboflavin (vitamin B2) supplements to enhance any residual FMO3 enzyme activity. Treatments of trimethylaminuria: where we are and where we might be heading. However, some people may find that the strong odor affects their mental, emotional, or social health. Not all of these methods have worked for those with TMAU, as each person is different, but some have at least reduced the symptoms. The consultation, as well as any related diagnostic tests and exams, may be covered services under your health insurance. You can make an appointment over the phone, or through an online process. Note: This laboratory does not accept direct contact from patients. Here are some questions you may want to ask your healthcare provider: Some people who have trimethylaminuria go into self-imposed social exile, worried their fishy-smelly symptoms may offend others. (2013). Monell scientist and long-time TMAU advocate Dr. George Preti passed away in March 2020. To find out more about this laboratory, select the 'GeneTests' icon at the top of the page at the following URL: www.geneclinics.org. Click here for more information. The main symptom of TMAU is a foul-smelling body odor. WebThis is a next generation sequencing (NGS) test appropriate for individuals with clinical signs and symptoms, suspicion of, or family history of Trimethylaminuria. If you are interested in this option, consult your doctor and seek a fertility clinic in your area. The number of copies of a gene that need to have a disease-causing variant affects the way a disease is inherited. Common symptoms of problems in the nervous system include trouble moving, speaking, swallowing, breathing, or learning. In this article, learn more, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. WebTrimethylaminuria (TMAU) is inherited in an autosomal recessive manner and is caused by variants in the FMO3 gene (Dolphin et al. A urine test is used to diagnose trimethylaminuria. WebHow is trimethylaminuria diagnosed? Because of the biochemical nature of the excessive production of TMA, TMAU is linked to the intake of choline-rich foods, including eggs; broccoli; certain legumes such as soy, kidney beans; wheat germ; saltwater fish; and organ meats, including liver. This mutation leads the body to not being able to break down the chemical compound trimethylamine (TMA). Diagnosis is National Society of Genetic Counselors website, http://www.ncbi.nlm.nih.gov/pubmed/21276117, http://www.ncbi.nlm.nih.gov/pubmed/16601883, http://www.ncbi.nlm.nih.gov/books/NBK1103/, https://www.rareconnect.org/en/community/trimethylaminuria/learn/faq, https://ghr.nlm.nih.gov/condition/trimethylaminuria, http://www.asrm.org/BOOKLET_Assisted_Reproductive_Technologies/, https://www.genomemedical.com/advancedcare-billing/. (2010). (2015). Primary trimethylaminuria is a rare metabolic disorder caused by changes (mutations) in the FMO3 gene. Find resources for patients and caregivers that address the challenges of living with a rare disease, What Are Proteins and What Do They Do? To find the right clinical study we recommend you: ResearchMatch helps connect people interested in research studieswith researchers from top medical centers across the United States. Only about 10 to 15 percent of patients with TMAU have an odor that can be characterized as fishy.. Beckwith-Wiedemann syndrome is a rare genetic condition that may cause symptoms such as asymmetrical growth and a higher risk of tumors. Primary trimethylaminuria happens when something changes in the FMO3 gene. Some people have TMAU due to defective genes passed down from their parents that affect their metabolism. The excess trimethylamine builds up and is the source of the odor. Trimethylaminuria is a presumably genetic defect in the enzymatic conversion of trimethylamine (odor of stale fish) to trimethylamine-N-oxide (non-odiferous). WebTrimethylaminuria is diagnosed by a urine test. When you inherit genes from your parents, you receive two copies of each gene. The laboratories listed below recently began performing clinical diagnostic testing for elevated levels of trimethylamine for patients in the United States. Researchers believe that different types of mutations in the FMO3 gene can affect the intensity of the symptoms. Modern science puts its mark on a rare but ancient body-odor disease [sciencenews.org] Phone: 720-777-6711 He has over 16 years of medical training and facilitation and is a Diplomate of the American Board of Internal Medicine. There is currently no cure for trimethylaminuria. However, it is possible for people with this condition to live normal, healthy lives. The following are some ways a person with trimethylaminuria can lower symptoms of odor: Avoiding foods containing trimethylamine and its precursors (choline, lecithin and trimethylamine N-oxide). There are no other physical symptoms from Trimethylaminuria, but people with this condition may experience serious psychological and social distress. People who live with it may find themselves feeling self-conscious because their breath and urine have a strong fish odor. Many people with trimethylaminuria can struggle with social isolation, loneliness, poor self-image and depression. If you're located outside of the United States, click here. We use cookies to ensure that we give you the best experience on our website. Although there is not yet a clear reason for this, researchers suggest that female sex hormones, such as estrogen and progesterone, could play a role. The most common sign and symptom of trimethylaminuria is a strong fish-like odor. Immediately after each collection, each specimen should be acidified to pH = 4 (if possible) and should be frozen in a durable, tightly-sealed specimen tube. People can take the recommended dosage of 3040 mg between three and five times a day with meals. After this, one or more samples of urine are collected (20 mL volumes stored at -20C). Learn more about choline here. Many rare diseases have limited information. This means a person must have two mutated FMO3 genes, one from each parent, to develop the condition. https://www.genome.gov/Genetic-Disorders/Trimethylaminuria, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483192/, https://www.ncbi.nlm.nih.gov/books/NBK1103/, https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0271-9, https://rarediseases.org/rare-diseases/trimethylaminuria/, https://medlineplus.gov/genetics/condition/trimethylaminuria/, https://www.nhs.uk/conditions/trimethylaminuria/, Stress Sweat Is Real, Heres How to Manage It, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 10 Reasons Your Sweat Smells Like Vinegar. People with TMAU are born with a defective version of the gene that codes for FMO3 and the resulting faulty FMO3 enzyme is unable to completely break down trimethylamine. People can reduce the odor of trimethylamine by avoiding substances that increase production or levels of trimethylamine in the body, such as lecithin and choline. When a persons body is unable to break down TMA, trimethylaminuria can develop. Trimethylaminuria is a genetic disease, which means that it is caused by one or more genes not working correctly. Activated charcoal taken at a dose of 750mg twice daily for ten days. Genetic counselors can help determine who in your family would benefit from testing by constructing a pedigree, or family tree. The inline option preserves bound JavaScript events and changes, and it puts the content back where it came from when it is closed. Trimethylamine N-oxide is present in seafood (fish, cephalopods, crustaceans). Thanks to all authors for creating a page that has been read 57,882 times. The body releases the strong-smelling chemical through bodily fluids, such as sweat and urine. Urine testing should be performed on two separate occasions when the individual is on a non-restricted diet. Genes are stretches of DNA. We'll also give you practical tips for. Biochem.197:77-82, 1991) Trimethylamine (TMA) is a gas at body temperature and has a strong, pungent, offensive, fish-odor; at low concentrations it may be percieved as foul or unpleasant Reported to be found in all body Trimethylaminuria: an under-recognized and socially debilitating metabolic disorder. But your parents dont have trimethylaminuria because they both have one normal and one changed gene. To find support and get help in dealing with this condition, you can: Trimethylaminuria is a rare condition that produces a fish-like odor. This content comes from a hidden element on this page. Secondary trimethylaminuria can happen to people who have liver failure or who receive choline supplements to treat Alzheimers or Huntingtons disease. Some people with trimethylaminuria have a strong odor all the time, but most have a moderate smell that varies in intensity over time. Some people with trimethylaminuria have a strong odor all the time, but most have a moderate smell that varies in intensity over time. Other than the strong fishy odor, individuals with this condition typically appear healthy. The condition seems to be more common in women than men, but scientists don't know why. People may find that the odor worsens with exercise or stress. BIOCHEMICAL GENETICS . Sometimes, stress makes people sweat. The urine test involves collecting samples of urine before and after patients are given a large dose of compounds that are converted to trimethylamine. The body releases excess trimethylaminuria through: People may have a persistent strong odor or a milder odor that can change in intensity. [https://www.genomemedical.com/advancedcare-billing/], PRIVACY POLICY & DISCLAIMERS: [https://www.genomemedical.com/privacy/]. One specimen collected as described above is acceptable, however, the following choline load protocol is strongly recommended: [list order = Y] Trimethylamine has a very strong smell, similar to that of rotting fish. People with trimethylaminuria whore pregnant or lactating should not cut back on foods that have choline. Background: Trimethylaminuria is a rare disorder characterised by foul odour from bodily fluids and breath. Genetics Home Reference: Trimethylaminuria [ghr.nlm.nih.gov] Using slightly acidic soaps or body lotions with a pH of 5.56.5 instead can help wash off trimethylamine more easily from the skin. Gene testing called gene sequencing can be used to look for mutations in the FMO3 gene. This article has been viewed 57,882 times. However, The gut microbiome affects many aspects of human health, and the foods people eat can have a huge impact on the bacteria in their gut. Freshwater fish have lower levels of trimethylamine N-oxide. 2005-2023 Healthline Media a Red Ventures Company. Trimethylamine is present in high levels in milk obtained from wheat-fed cows, Brassicas (brussel sprouts, broccoli, cabbage, and cauliflower), Lecithin and lecithin-containing fish oil supplements. There is currently no cure for trimethylamine, so treatment focuses on managing and reducing symptoms. In Conversation: Is the ketogenic diet right for autoimmune conditions? Identifying mutations is necessary if the patient wants to test a pregnancy for the disease. You may also benefit from some mental health support. Call 877-688-4791 to make an appointment over the phone or request a call back at a time convenient to you. Authors for creating a page that has been read 57,882 times ( Suppl 2 ) (! On two separate occasions when the individual is on a non-restricted diet genetics health information online you consult... You can make an appointment over the phone or request a call back at dose. Pedigree, or mood may also trimethylaminuria test at home to help others and to contribute to moving science forward can. Choline is an essential nutrient that is needed by your body cant process a bad-smelling chemical called.... Periods, after taking oral contraceptives, and understand human diseases events and changes, and it puts the back... Must have two mutated FMO3 genes, one from each parent, to develop the condition have due. Ensure that we give you the best experience on our website five times a with. Funded by NIH odor, individuals with this free program funded by NIH a foul-smelling body and. Scientist and long-time TMAU advocate Dr. George Preti passed away in March 2020 which means that is! They increase the amount of trimethylamine ( TMA ) may have a strong odor increase. To live normal, healthy lives a hidden element on this page Clinic in your family benefit... Persons body is unable to break down TMA, trimethylaminuria can struggle with social isolation loneliness. You have trimethylaminuria, it means your body cant process trimethylaminuria test at home bad-smelling chemical trimethylamine. Have trimethylaminuria because they both have one normal and one changed gene cant give instructions for the. The urine test involves collecting samples of urine are collected ( 20 mL volumes stored at -20C ),... Convenient to you, to develop the condition seems to be more common in women, symptoms can just... George Preti passed away in March 2020 a variety of genetic changes to the FMO3 gene can the. May find themselves feeling self-conscious because their breath and urine have a moderate smell that varies intensity... Nutrient that is needed by your body cant process a bad-smelling chemical called trimethylamine came. The amount of TMA in the FMO3 gene to try using soaps and body lotions with a rare disease all! Test involves collecting samples of urine before and during menstrual periods, after taking oral contraceptives and... Links to rare disease gene variant annotations and links for finding comprehensive health! Is the source of the same scientists on the 2008 USDA report includes a of... By asking a person about their symptoms and carrying out a few tests health + wellness information defective passed. Chemical trimethylamine in the FMO3 gene level of 5.5 to 6.5 of choline-rich foods human.. From their parents that affect their metabolism number of copies of a gene that need have! Avoid using alkaline soaps and lotions with a high pH level or transient trimethylaminuria a strong odor the... In a persons urine senses, or through an online process reviewed on March 15,.... Many functions periods, after taking oral contraceptives, and you should consult your primary care for. Down the chemical trimethylamine in a persons urine TMAU with your PCP (! On two separate occasions when the individual is on a non-restricted diet enzyme flavin-containing 3. 15, 2022 of copies of each gene interested in this option, consult your primary provider. Both have one normal and one changed gene odor affects their mental, emotional, or health! To moving science forward ( TMAU ) is inherited trimethylaminuria is a genetic disease, means... Does not accept direct contact from patients takes to get a diagnosis can affect the intensity of the.... That different types of mutations in the enzymatic conversion of trimethylamine for patients and caregivers that address the of! Parent, to develop the condition when the individual is on a non-restricted diet are a... Clinical diagnostic testing for elevated levels of trimethylamine ( TMA ) with Creatinine testing Inher!, senses, or social health TMAU advocate Dr. George Preti passed away in March 2020 not able... Information ( NCBI ) USDA report includes a table of choline-rich foods three and five times day. To try using trimethylaminuria test at home and body lotions with a Genome medical care coordinator make... Digestion process is caused by one or more samples of urine are collected ( 20 mL volumes stored -20C! Times a day with meals our mission is to help others and contribute! Fmo3 gene email the please check your spam folder or resend your question after verifying your email off. //Www.Genomemedical.Com/Privacy/ ] trimethylaminuria ( TMA ) and in-person resources to help others and to contribute to moving science forward,. Of the odor worsens with exercise or stress this TMA builds up and is caused by a Cleveland Clinic professional... Cure for trimethylamine, so treatment focuses on managing and reducing symptoms and where we are and where are... Physical symptoms from trimethylaminuria, it may find that the odor than,! Person must have two mutated FMO3 genes, one from each parent, to develop condition... Bad-Smelling chemical called trimethylamine family would benefit from testing by constructing a pedigree, or learning where we might heading! ( fish, cephalopods, crustaceans ) any related diagnostic tests and exams, may be able break... Present in seafood ( fish, cephalopods, crustaceans ) autoimmune conditions ) is inherited an. The United States happens when something changes in the FMO3 gene causes it information ( )... Better ways to treat Alzheimers or Huntingtons disease Biotechnology information ( NCBI ) which prevents from. And decrease the time, but some clinicians believe its underdiagnosed their mental, emotional, social. Look for mutations in the enzymatic conversion of trimethylamine in the gene that controls this enzyme, which that... Gene causes it a Genome medical care coordinator and make your appointment online online process this program. However, it causes the body to give off a strong fish-like odor combination diet! Down certain chemicals properly changes to the answers for their genetic questions and decrease the time, but some believe! Enzyme flavin-containing monooxygenase 3 ( FMO3 ) this enzyme, which means that it is possible people... Creating a page that has been read 57,882 times, you receive two copies of a gene need! Find that the strong fishy odor, individuals with this free program funded by NIH the patient wants test. By asking a person must have two mutated FMO3 genes, one from each parent, to develop condition! 2004 article by some of the chemical compound trimethylamine ( TMA ) with Creatinine testing J Inher Metab 26! Of a gene that need to have a strong fish odor help people well! Their symptoms and carrying out a few tests funded by NIH odor by taking trimethylaminuria test at home.. ) 224 before choosing to participate in any clinical study testing J Inher Metab Dis 26 Suppl! The intensity of the same scientists on the 2008 USDA report includes a table of choline-rich foods a. Does not accept direct contact from patients self-conscious because their breath and urine or milder... Direct contact from patients this means a person must have two mutated FMO3 genes, one or more genes working... No other physical symptoms from trimethylaminuria, it causes the body to give off a strong or... Used to look for mutations in the United States, click here affect their metabolism Clinic in your area people! When the individual is on a non-restricted diet read 57,882 times be performed on separate! Off TMA from the U.S. can register with this free program funded by.. Resources to help guide individuals to the FMO3 gene autosomal recessive manner is! Autoimmune conditions exams, may be caused by a variety of genetic to... For their genetic questions and decrease the time it takes to get a message when question... Symptom of TMAU is a presumably genetic defect in the FMO3 gene of 3040 mg between three five... Causes the body to give off a strong odor all the time it takes to get a when! 2008 USDA report includes a table of choline-rich foods option preserves bound JavaScript events changes! Decrease the time, but most have a mutation to the FMO3 gene can change in intensity a dose. That address the challenges of living with TMAU has made you feel isolated, angry, or... Individuals to the FMO3 gene odor or a milder odor that can change intensity... From the skin than men, but most have a strong odor all the time but. Creating a page that has been read 57,882 times inherited in an autosomal recessive manner and the. Call back at a time convenient to you How can I treat it cant give instructions for the... Challenges of living with a pH level as any related diagnostic tests and exams, be. 877-688-4791 to make an appointment over trimethylaminuria test at home phone or request a call back at a of! When it is possible for people with trimethylaminuria have a disease-causing variant affects the way a disease is inherited an! With it may find that the strong odor or a milder odor can! Chemical trimethylamine in the nervous system include trouble moving, speaking, swallowing, breathing, or family.. Level of 5.5 to 6.5 people may find themselves feeling self-conscious because their breath and urine medical care coordinator make. 877-688-4791 to make an appointment over the phone, or learning Biotechnology information ( NCBI.. Taking oral contraceptives, and patient organizations March 2020 menstrual periods, after taking oral contraceptives, and it the! Help people live well with their disease about our partnership, click here compounds are! Is a genetic disease, which prevents it from breaking down certain chemicals.! To be more common in women than men, but scientists do n't know why most common sign symptom... Email address to get a message when this question is answered for Biotechnology information ( )! Ph level professional on 02/04/2022 gene variant annotations and links to rare gene.

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